韓晶岩学院長らが国際雑誌にて発表した中医薬を研究する科学論文

（ 2005 年― 2007 年）

1 ． Y. Horie, J-Y. Han*, S.Mori, M. Konishi, M. Kajihara, T. Kaneko, Y-Y-S. Kato, H. Ishii and T. Hibi, Herbal cardiotonic pills prevent gut ischemia/reperfusion induced hepatic nicrovascular dysfunction in rats fed ethanol chronically, World J. Gastroenterol. 1 1 ( 2 0 0 5 ), 5 1 1 - 5 1 5 .

2. K. Sun, C-S. Wang, J. Guo, Y-Y. Liu, F. Wang, L-Y. Liu, J-Y. Fan and J-Y. Han*. Effect of Panax notoginseng saponins on LPS-induced adhesion of leukocyte to venule wall in rat mesentery, Clin. Hemorheol. Microcirc. 3 3 (2005),103-108

3. F. Wang, Y-Y. Liu, L-Y. Liu, J. Guo, K. Sun, C-S, Wang, J-Y. Fan and J-Y. Han*. Inhibition effect of cardiotonic pills on rat mesentery thrombosis induced by photochemical reaction, Clin. Hemorheol. Microcirc. 3 3 ( 2 0 0 5 ), 131-138

4. J-Y. Han*, Y.Horie, D. Li, Y. Akiba, H, Nagata, S. Miura, M.Oda, H.Ishii and T.Hibi, Attenuating effect of “Myakuryu” on mesenteric microcirculatory disorders induced by ischemia and reperfusion, Clin. Hemorheol. Microcirc. 3 3 (2005),145-150.

5. Hideyuki Niimia,b, Suthiluk Patumrajc and Jing-Yan Han . Asian traditional medicine (ATM): recent progress based on scientific evidences Clin. Hemorheol. Microcirc. 3 3 (2005),85-88

6. Masaya Oda*, Hiroaki Yokomori, Jing-Yan Han . Regulatory mechanisms of hepatic microcirculatory hemodynamics: hepatic arterial system. Clin. Hemorheol. Microcirc. 3 3 ( 2 0 0 5 ), 11-26

7 ． Guo J, Sun K, Wang, C-S, Fang S-P, Horie Y, Yang J-Y, Liu Y-Y, Wang F, Liu L-Y, Fan J-Y, Hibi T and Han J-Y*. Protective effects of dihydroxylphenyl lactic acid and salvianolic acid b on lipopolysaccharide-induced mesenteric microcirculatory disturbance in rats. Shock. 2007

8. Sun K, Wang C-S, Guo J, Horie Y, Fang S-P, Wang F, Liu Y-Y, Liu L-Y, Yang J-Y, Fan J-Y and Han J-Y*. Protective effects of ginsenoside Rb1, ginsenoside Rg1 and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Sci,81(2007)509-518.

9. Han J-Y*, Horie Y, Miura S, Akiba Y, Guo J, Li D, Fan J-Y, Liu Y-Y, Hu B-H, An L-H, Chang X, Xu M, Guo D-A, Sun K, Yang J-Y, Fang S-P, Xian M-J, Kizaki M, Nagata H, Hibi T: Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery. World J Gastroenterol 2007 14;13(26);3581-3591

10. Chen W-X, Wang F, Liu Y-Y, Zeng Q-J, Sun K, Xue X, Li X, Yang J-Y, An L-H, Hu B-H, Yang J-H, Wang C-S, Li ZX, Liu L-Y, Li Y, Zheng J, Liao F-L, Han D, Fan J-Y and Han J-Y*. The improving effects of Notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion. World J Gastroenterol 2008 7:14(1):49-57

11. J-Y Han*, J-Y Fan, Y Horie, S Miura , D-H Cui, H Ishii, T Hibi, H Tsuneke and I Kimura. Amwliorating effects of compounds derived from salvia miltiorrhiza root extract on microcirculatiory disturbance and target-organ injury by ishemia-reperusion. Pharmacology and Therapeutics 2008 117:280-295

12.Yang J-Y, Sun K, Wang C-S, Guo J, Xue X, Liu Y-Y, Zheng J, Fan J-Y, Liao F-L, Han J-Y. Improving effect of post-treatment with panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Clinical Hemorheology and Microcirculation 2008;40(2):119-31.


13. Wang F, Liu Y-Y, Liu L-Y, Zeng Q-J, Wang C-S, Sun K, Yang J-Y, Guo J, Fan J-Y, Han J-Y. The attenuation effect of 3,4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction. Clinical Hemorheology and Microcirculation.2008 (in press)


14. Xu X-S, Ma A-Z, Wang F, Hu B-H, Wang C-S, Liu Y-Y, Zhao X-R, An L-H, Chang X, Liao F-L, Fan J-Y, Niimi H, Han J-Y. The antioxidant cerebralcare granuleR attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. 2008 Shock (in press)


15. Han J-Y, Horie Y, Fan J-Y, Sun K, Guo J, Miura S, Hibi T. Potential of 3, 4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion-induced microvascular disturbance in rat mesentery. Americ Journal of Physiology-Gastrointestinal and Liver Physiology.2008 (in press)

韓晶岩学院長が 学会での講演（ 2008 年〕

2007年
1 ） Multi-targeting potential of compound danshen injection for improving endotoxin-induced microvascular damage in rat mesentery

(Symposium 発表 , The 32th annual meeting of Japanese society for microcirculation, 07, 2 kyoto)

2) 脳血管障害に対する中医薬の改善効果

（ Symposium 発表 ， 第 7 回日本抗加齢医学会総会、０７，７。京都）

3 ） 微小循環障害と中医薬

（ Symposium 発表 ， 第一回中西医結合学会アレルギー国際学会、０７、７。青島）

5 ） 中薬と保険食品作用原理研究に関する新方法

（ 口演 ， 第９回日本天然薬物方法論研究会、０７，７埼玉 ）

6 ） 虚血再灌流によるラット心臓微小循環障害と心筋障害に対する複方丹参滴丸 の改善作用

（ Symposium 発表 ， 第６回中国台湾香港心血管科学研究会、０７，８新 疆 ）

7 ） Improving effects of dihydroxyphenyl lactic acid on microcirculatory disturbance

(Symposium 発表 ， 8th world congress for microcirculation,07, 8. Milwaukee,USA)

8) Protective effects of total salvianolic acid on ischemia-reperfusion-induced microvascular damage in rat mesentery

( Post 発表 ， 8th world congress for microcirculation,07, 8. Milwaukee,USA)

9) Multi-targeting potential of 3,4-dohydroxu-phenyl lactic acid for inmproving ischemia-reperfusion-induced microvascular damage in rat mesentery

( Post 発表 ， 8th world congress for microcirculation,07, 8. Milwaukee,USA)

10) Protective effect of cardiotonic pills against myocardial ischemia-reperfusion-induced microcirculatory disturbances and myocardial damage

( Post 発表 ， 8th world congress for microcirculation,07, 8. Milwaukee,USA)

11) Leckocytes and endothelial cells interaction during endotoxin-induced microcirculatory disturbances and the attenuating effects of major saponins of panax notoginseng in rat mesentery

( Post 発表 ， 8th world congress for microcirculation,07, 8. Milwaukee,USA)

12) The atteuation effect of cerebralcare granules on the microcirculatory disturbance in mongolia gerbil brain induced by occlusion of both carotid arteries and reperdusion

( Post 発表 ， 8th world congress for microcirculation,07, 8. Milwaukee,USA)

13 ）虚血再灌流によるモンゴルゲラビ脳微小循環障害に対する養血清脳顆粒の改善効果

　　〔口演、第 24 回 日本和漢医薬大会、０７，９富山〕

2008年

１）第3回日本微小循環学会（シンポ01室）

２）中国中西医結合学会２００８微小循環大会特別講演

３）世界科技→中医薬現代化年会

　　活血化お中薬阻害血お原理